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Across the cagrilintide clinical program, the dominant tolerability issues have been gastrointestinal: nausea, reduced appetite, constipation, and, less commonly, vomiting a profile shared with pramlintide and with GLP-1 agonists, and mechanistically expected from a compound that slows the stomach and engages the area postrema

This is a common disorder and dry lips are often accompanied by a cracked tongue, a dry throat, digestive issues, and joint pain

How GLP-1 medications affect oral drug absorption When you take an oral medication, it travels to your stomach, dissolves, moves to the small intestine, and gets absorbed into your bloodstream

And when you have, in fact, GLP-1 receptors in regions of the brain, it can often tell you a bit about what its job description is