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Researchers are exploring nanotechnology-based medication delivery systems to improve renal treatment, addressing traditional drawbacks like stability, solubility, and toxic effects, making NPs a promising tool for disease diagnosis and treatment 26

In terms of potential antitumor activity, -glutamyl-protected N -hydroxyguanidines (NHGs) have been developed to explore the ability to deliver NO to the kidney ( Figure 5A )

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For example, osteoblasts express receptor activator of NF-kB (RANK) ligand (RANKL) to activate the RANK on the surface of osteoclast precursors, and induce the differentiation of the latter cells (66)