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Glutamate cysteine ligase (GCL) catalyzes ligation of cysteine and glutamate forming -glutamylcysteine (-GC)

In complexes containing five, seven, eight, or higher coordinate metals a number of geometries that are similar in energy to the preferred geometry

Nevertheless, oxidative stress and H 2 O 2 were described to activate multiple stress-sensitive Ser/Thr kinases such as JNK, ERK1, and IKKb (inhibitor of NF- B), and p70S6k, which take part in insulin resistance by phosphorylation of IRS1 in serine instead of tyrosine residue, blocking insulin signaling [41]