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Vasoconstriction due to endothelial dysfunction is a common mechanism involved in hypertension related cardiovascular events ( In a study at the University of Zurich with 23 patients with coronary artery disease, endothelial function was assessed by measuring the flow-mediated dilatation (FMD) of the brachial artery ( per day or placebo was supplemented in a RDP cross-over study for eight weeks
In an ovalbumin-induced chronic asthma mouse model, liraglutide markedly inhibited the up-regulation of MUC5AC, leading to a decreased mucin hypersecretion [103]
By the 1990s it had become apparent that GLP-1 not only played an important role in the stimulation of insulin but could also have broader physiological actions beyond the pancreas
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