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Confinement exerts stress on the nucleus, triggering the formation of nuclear protrusions (aka nuclear blebs), which lack lamin B1 and nuclear pores and lead to transient ruptures of the nuclear envelope [188,189,190]

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d-i , Autochthonous tumors from MMTV-PyMT Gclc f/f Rosa26-CreERT2 mice were excised and orthotopically transplanted into the mammary gland or subcutaneously transplanted into the flank of wild-type C57BL/6 mice, which were treated with vehicle (corn oil