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have demonstrated that argirein medication, by inactivating NADPH oxidase, can prevent endothelial cell apoptosis in a rat model of T2DM and hence attenuate vascular dysfunction ( 2 O 2 and HN decreases the intracellular levels of ROS, preserve mitochondrial function/structure and decline cellular apoptosis ( EC activation and expression of adhesion molecules also facilitate activation and adhesion of platelets

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