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American Diabetes Association Transitions Working Group

At the center of the issue is a growing concern that some companies are promoting compounded versions as if theyre equivalent to FDA-approved medications, even though these products are not reviewed for safety, effectiveness, or quality by the agency

Although DPP-4 inhibitors have a strong safety profile, they did not improve cardiovascular outcomes in large clinical trials of patients who have diabetes, mostly those with established CVD, and they are expensive