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The 4 mg arm landed near the territory that semaglutide occupies, the 8 mg arm matched what tirzepatide achieves at its top dose, and the 12 mg arm went somewhere no single or dual agonist had reached in a trial of that size

Material and methods Materials Tamoxifen, 4-hydroxy-tamoxifen, Dimethylsulfoxide, 2,7-dichlorofluorescin diacetate, 5,5-dithio-bis (2-nitrobenzoic acid), colchicine, valspodar (PSC-833) and Tween-20 (P9416) were all purchased from Sigma Aldrich

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While offering greater sensitivity and visible-range measurements with reduced interference, these endpoint assays preclude continuous monitoring and require precise reaction termination timing