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Importantly, donors should postpone donation if experiencing severe or persistent abdominal pain, acute pancreatitis symptoms, acute gallbladder disease, or ongoing vomiting or diarrhoea, and seek medical advice

Conversely, a pre-existing restriction in this fiber-fermenting machinery could blunt this supportive postbiotic feedback loop, offering a plausible microbial rationale for the sub-optimal metabolic responses observed in non-responders (40, 58)