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These Authors failed to evidence significant changes in indexes of insulin resistance and speculated that other classical effects of GLP-1 RA, such as suppressed glucagon secretion, with consequent reduced hepatic glucose production, could have been involved in the improvement in glucose metabolism and ectopic fat deposition [54]

On average, people were losing 15% to 20% of their body weight, which had never been seen before with an FDA-approved weight-loss drug

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