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Some clear triggers to stop and contact a clinician include: New or worsening hypothyroid symptoms or an unexpected rise in TSH Unexplained INR instability if you are on warfarin New seizures or increased seizure frequency Evidence gaps and how clinicians can manage uncertainty Large randomized trials of supplement-drug interactions are rare

Clinical trials[1] reveal that tirzepatide can achieve up to 22% body weight reduction and over 2% absolute HbA1c improvement, results unmatched by any previous incretin-based therapy

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