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Notably, however, while several of these technologies have shown promise in a pre-clinical setting, additional high quality randomized evidence is required before advocating for their widespread clinical adoption ( 3.3 Sperm surface characteristics In common with their somatic cell counterparts, the surface of a human spermatozoon is furnished with a complex glycocalyx comprising a diversity of carbohydrates linked to membrane protein and lipid anchors ( Figure 1 )