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In pancreatic ductal adenocarcinoma FOXO3 is able to induce stem cell properties, associated with poor prognosis and possibly metastasis [118, 119]

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Ghassemifar MR, Olsson MG, Agren MS, Franzen LE

In tumors developing at mucosal barrier sites, these heterogeneous features are further shaped by the unique immunological context of mucosal tissues, where immune tolerance, chronic inflammation, and continuous antigen exposure create permissive environments for immune escape and adaptive resistance