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Onset: 46 weeks for cognitive effects

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A 30-year-old likely has far fewer senescent cells than a 60-year-old, which means: Younger individuals may notice less from FOXO4-DRI simply because there are fewer target cells to clear Older individuals or those with conditions associated with accelerated senescence (chronic inflammation, metabolic syndrome, prior chemotherapy) may have more to gain and more pronounced initial side effects from a larger clearance event Overall Health and Immune Function The immune system must clear apoptotic cells after FOXO4-DRI triggers their death

This is exactly the same principle as the elimination process controlling the time to accumulate to steady state with a constant rate infusion (see Figure 33 )