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It is due to the inactivation of the glutathione (GSH)-dependent antioxidant defense mechanism in cells, and the ability of GPX4 to suppress lipid ROS accumulation is inhibited, which eventually leads to lipid peroxidation and cell death ( Three factors are closely related to ferroptosis: iron, polyunsaturated fatty acids, and amino acids

Structural and enzymatic insights into Lambda glutathione transferases from Populus trichocarpa, monomeric enzymes constituting an early divergent class specific to terrestrial plants

Reactants (as indicated in the figure legends) were mixed in PBS

It can trigger cellcycle arrest, repair or apoptosis