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putida led to the induction of several host genes that encoded defense-related proteins such as PR-1, PR-4, catalase, metallothionein, and a GST (Agisha et al., GSTs may significantly increase plant disease resistance

However, excessive NFE2L2 activation may also promote intracellular cysteine accumulation, which can react with sugars to form adducts that impair cell proliferation 163

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Studies in the model organism Caenorhabditis elegans have demonstrated that different FOXO isoformsparticularly DAF-16Aexert a significant influence on lifespan extension by activating or repressing specific genes such as gst-20 and srr-4, which either promote or inhibit longevity-associated mechanisms