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6 Aging leads to a decrease in neuronal mitochondrial [NADH] that is restored in vitro by cysteine supplementation Fluorescence lifetime measurement (FLIM) studies have shown that a decrease in mitochondrial NADH abundance occurs in cultured neurons from aged mice compared to that from young adult mice, which likely indicates an oxidation of the mitochondrial [NAD + ]/[NADH] in aged neurons (Dong et al., 2019a)

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2022;9 doi: 10.3389/fnut.2022.971879

Appetite suppression, delayed gastric emptying, and altered absorption are all considered plausible contributors to increased micronutrient deficiency risk