why does semaglutide burn when injected Injected? Injection Site Reactions Wegovy and Injection Site Reactions:

Am J Hematol 94(3):E78E80

While the effects of GLP-1 signaling on food cue reactivity in rodents have not been investigated as extensively compared to ghrelin, a recent study demonstrated that icv infusion of the GLP-1R agonist exendin-4 inhibits both phasic firing of ACB-projecting VTA dopamine neurons and food anticipatory approach behaviors in response to sucrose-predictive cues in rats [20]

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Consequently, the translational relevance of current clinical data should be interpreted with caution, and larger, well-controlled trials with standardized dosing strategies are needed