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These findings highlight the complexity of metformins effects, which may be age-, genotype-, and disease-context dependent, reinforcing the need for further experimental and clinical validation to clarify its therapeutic potential and risks in AD prevention across different populations

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Science 330 , 10661071 (2010)

Individuals under metformin treatment showed positive correlations were found with Bacteroids and Escherichia species and negative associations were obsevered with Ruminocococus and Faecalibacterium even with shorter duration of metformin treatment in Japanese cohort (Li et al., 2021)