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Tirzepatide (Mounjaro/Zepbound) Timeline Phase 3 trials began: 2019 (SURPASS program for diabetes) FDA approval (Mounjaro for diabetes): May 2022 Commercial availability: June 2022, initial supply constraints Zepbound (obesity indication) Phase 3: 2020-2022 (SURMOUNT program) Zepbound FDA approval: November 2023 Zepbound commercial launch: December 2023, immediate shortages Stable widespread availability: Still not fully stable as of early 2026

A careful physical examination follows, including checking vital signstemperature, blood pressure, and heart rateto detect signs of a more serious condition

Eli Lilly's industry-leading GLP-1 drugs Mounjaro and Zepbound, for example, saw revenue growth of 99% and 175%, respectively, in 2025

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