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Experimental data on animal models have suggested that GIP suppresses peripheral arterial remodeling, thus showing an anti-atherosclerotic activity, by acting on receptors in the heart and vessels." Outcomes of clinical trials The first clinical trial to test the clinical efficacy of TZP was the SURPASS program, a six-stage trial conducted on three separate cohorts Japanese (SURPASS-J), Asian-Pacific (SURPASS-AP), and the cardiovascular outcome trial (SURPASS-CVOT)
However, its regulatory history under both designations is extensive and requires separate treatment
Furthermore, 5-Amino-1MQ remains a relevant material within research programs focused on compound characterization and analytical investigation
Figure modified from Zheng et al (2024), an open access publication
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