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The term pernicious is also an anachronism, predating the 1948 discovery of B as an effective treatment

Thus, we hypothesized that the major role of ROS during initiation of EBV reactivation might be in enhancing the p53 transcriptional function via activation of ATM, p38 MAPK and JNK

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Common symptoms of a vitamin B12 deficiency include: Tiredness Lethargy Feeling faint Breathlessness Less common symptoms include: Headaches Heart palpitations Altered taste Loss of appetite Ringing in the ears (tinnitus) Looking pale Sore mouth and tongue If it is left untreated you can end up with longer term problems including: Psychological problems such as depression, confusion, memory problems Nerve problems such as numbness, pins and needles, vision changes and unsteadiness A blood test can indicate if you have a B12 deficiency