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Wegovy may cause an increased risk of suicidal thoughts or actions, which can include symptoms of depression

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However, compared with native GLP-1, which is rapidly degraded and has a short half-life of approximately 2 min, semaglutide has been structurally modified by the addition of a hydrophilic spacer and a fatty acid side chain, allowing reversible binding to albumin [36]

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May 2, 2022

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