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L-carnitine supplementation has been associated with improved insulin sensitivity and glucose uptake, which could be beneficial in managing or preventing type 2 diabetes, Zenker says

Another limitation is the focus on change in drug absorption, whereas other PK parameters can be considered

A substantial proportion of the mechanistic and clinical evidence also originates from a limited number of research groups and device/protocol platforms, which may constrain external validity across broader implant systems and clinical environments

This concentration also makes the standard dose escalation math clean and intuitive