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After extended follow-up, the difference reached significance, however, and individuals who switched from Vykat XR to placebo in a 16-week withdrawal phase after an average of more than three years on the drug demonstrated a statistically significant worsening of hyperphagia compared with those who remained on it

The increased inflammatory environment may cause insulin resistance and reduced glucose uptake in insulin-sensitive tissues (muscle and liver), thereby causing glucose intolerance

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After the initiation of apoptosis, PS loses its asymmetric distribution and moves to the outer part of the cell membrane