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This might include: Adding SGLT2 inhibitors (such as dapagliflozin or empagliflozin), which work through a different mechanism by increasing urinary glucose excretion and offer cardiovascular and renal benefits

118 In accordance with this notion, ATII was shown to increase mitochondrial ROS production in a Nox-dependent manner 119 and vice versa

However, with stronger glucagon receptor stimulation, it would be important for further pre-clinical studies to characterise the effects of lead drug candidates, on plasma amino acids and lean mass

Advances in recombinant DNA technology later enabled the development of additional peptide therapies, including GnRH analogs, somatostatin analogs, and calcitonin derivatives (Wang, 2022)