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These observations strongly support the current hypothesis that reactive metabolite formation and protein binding especially in mitochondria are the key initiating events in the toxicity, which is then the trigger for a moderate mitochondrial oxidant stress with release of superoxide by complex III towards the cytosol without compromise of mitochondrial respiration [33]
In the STEP 4 trial, people who stopped semaglutide abruptly regained weight over the following months
However, concentration, stability, and sterility are variables that matter
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