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Furthermore, exendin-4 increased the membrane protein levels of the AMPA receptor GluR1 subunit and PSD-95.139 Liraglutide also rescued the deleterious effects of a high-fat diet on hippocampal LTP of neurotransmission140 and enhanced the number of hippocampal and cortical synapses in AD model mice.141 The effect of GLP-1 RA on synaptic plasticity is partly due to the GLP-1R

These ROS can damage the cell structure, cause cell death and dysfunction, and ultimately exacerbate muscle atrophy [33]

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Metabolic Resilience Even without diabetes, many people experience post-meal crashes, cravings, or metabolic sluggishness