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The first is where the catechol-O-methyltransferase (COMT) enzyme, which helps degrade stimulatory compounds such as dopamine and adrenaline, does not work properly and lets these compounds accumulate in the nervous system

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These results held true across diverse patient populations, including those with existing type 2 diabetes and those with insulin resistance alone

Read clinical review A clinical comparison of Wegovy (semaglutide 2.4 mg) and Trulicity (dulaglutide) covering efficacy, indications, and how to switch between them with proper dose mapping and washout timing