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The increase in ROS or RNS levels involves a concomitant increase of proinflammatory cytokines and the activation of NF-, which in turn activates the hepatic stellate cells, the subsequent fibrosis, and damage to the DNA [12,64], with a failure in the synthesis of exogenous antioxidants [12]

Methods We used data from nationwide registers in Sweden to perform separate analyses for all patients with type 2 diabetes who filled a first prescription of a GLP-1 receptor agonist or an SGLT2 inhibitor between 2017 and 2021

In addition, HIV and hepatocellular carcinoma patients have increased levels of protein carbonyls

The extracted samples were separated using a Waters Acquity UPLC BEH C18 column (2.1 100 mm) on a Shimadzu Nexera UHPLC at 60 C with 0.7 mL/min flow rate, and detected using a SCIEX TripleTOF 6600 operating in full scan + MS2 positive ion mode or a SCIEX 5500 operating in MRM positive ion mode, or a Thermo TSQ Vantage operating in MRM mode