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Sawicka-Gutaj and colleagues, in International Journal of Obesity (April 2026), pooled 24 trials and concluded GLP-1 RAs deliver "quality" weight loss with relatively preserved lean tissue reductions of approximately 14% in lean body mass across treatment durations from 3 to 12 months

Assessment of mechanical allodynia in CCI rats After habituation of rats in plastic cages located on a metal wire mesh floor (1 h/day for two consecutive days), paw withdrawal threshold was measured as the average of three measurements with 3 to 5 min interval between applications using electronic von Frey apparatus (panlab, Harvard, Spain)

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