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Hepatocyte necrosis within the centrilobular region can be visualised by an absence of rhodamine 123 staining and acquisition of nuclear propidium iodide staining

In other words, if a pharmaceutical company thinks it can make a prescription drug out of a popular supplement ingredient, it can file a new drug application for a patented form of that ingredient, and the FDA will put out a letter stating that further sales of that ingredient in supplement form are prohibited

The formulation and manufacturing process are the same for all three products

This effect could be attenuated by pre-surgery exposure to sucrose [77]