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Typical protocol structure: Dose: 100-200mcg based on individual response Frequency: 3-5 times per week Timing: 1-3 hours before bed (experiment to find your optimal window) Cycle length: 4-8 weeks Break period: 2-4 weeks between cycles The frequency debate generates significant discussion

The prominent lymphocytic inflammationat least in the earlier relapsing phase of the diseaseis traditionally thought to be the primary insult with immune cells recruited into the CNS to induce recurrent chronic injury (Box 1)

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The role of NAD-related compounds in neuroprotection adds another dimension