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cGAS-STING activation contributes to podocyte injury in diabetic kidney disease

Downstream, an independent 2021 study in APP/PS1 mice linked the memory effect to PI3K/AKT signaling, blocked by the inhibitor wortmannin [3] coherent, but still a mouse result

But as discussed, the kidney's OCTN2 transporter reabsorbs carnitine with such high efficiency that plasma levels stay well above the symptomatic threshold