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In one trial of people with obesity and knee osteoarthritis, top-line results released in late 2025 showed that those receiving 12 mg weekly achieved 2226% average weight loss over 68 weeks , while the placebo group lost only around 2.5%

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J Physiol Biochem 72(4):763779 Nehra S, Bhardwaj V, Kar S, Saraswat D (2016b) Chronic hypobaric hypoxia induces right ventricular hypertrophy and apoptosis in rats: therapeutic potential of nanocurcumin in improving adaptation

That muscle is essential for daily function, metabolism, and long-term health