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The accelarating pace of discovery, including the identification of new regulatory networks and the complex interplay with redox imbalance, metabolic reprogramming, and inflammation, underscores the need for a timely and comprhensive synthesis

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Evidence from genetically engineered mice lacking GLP1 receptors in specific tissues, infusion of GLP1 receptor agonists directly into the brain, and optogenetic or chemogenetic stimulation of neuron populations all indicate that central rather than peripheral mechanisms underlie the ability of GLP1 receptor agonists to reduce intake of drugs and alcohol (Abtahi et al., 2018

Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader