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Chronic daily administration of an amylin receptor or GLP-1R analog as a mono- or combinatorial-therapy on body weight gain and food intake Experiments were designed to determine whether chronic combinatorial administration of an amylin receptor agonist with a GLP-1R agonist is superior in producing a greater magnitude of sustained weight loss and food intake suppression compared to monotherapy in a diet induced obese rat model

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Systemic complications refer to new-onset organ failure (involving the respiratory, cardiovascular, or renal systems) or acute exacerbation of pre-existing comorbidities