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Your doctor should evaluate your current mental health status thoroughly

The Risk of "Extreme" Fasting: Longer fasts combined with GLP-1 therapy can lead to insufficient nutrient intake, which triggers muscle atrophy and a "yo-yo effect" once the medication is stopped

Weight Loss with Semaglutide Average loss: 1416% of body weight Key trial: STEP 1 (New England Journal of Medicine) Population: Obese individuals without diabetes Notable: Significant appetite suppression and better cardiometabolic parameters reported by most participants Weight Loss with Tirzepatide Average loss: 21% or more of body weight at highest dose (15 mg) Key trial: SURMOUNT-1 Population: Obese and overweight adults without diabetes Remarkable: Highest rate of any FDA-approved weight loss medication to date Clinical Insight: Tirzepatide always beats Semaglutide in weight reduction

But these health issues may raise your risk: Diabetes High blood pressure High cholesterol Obstructive sleep apnea Taking certain medications (PDE4 inhibitors) Smoking Eye problems that can increase your risk include: Previous NAION in one eye A naturally crowded optic nerve (called disk at risk) Having prior eye surgery You can still take semaglutide or other GLP-1 drugs if you have these conditions