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High levels of prolactin make you less sensitive to leptin, a hormone that regulates appetite

Any patient currently on tirzepatide 15 mg who wants to trial retatrutide should discontinue tirzepatide first, allow at least two weeks for GI recovery, and begin retatrutide at the 2 mg starting dose with standard titration [2][4]

Common early effects include: Reduced hunger between meals Smaller portion sizes feel satisfying Decreased interest in high-calorie or high-sugar foods A quieting of intrusive food-focused thoughts (sometimes called "food noise") The starter dose of 0.6mg is intended primarily to help your body adjust to the medication

10.1016/j.heliyon.2024.e24779 96 QiuL