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Adjunctive use of sodiumglucose cotransporter (SGLT) inhibitors (see below) in adults with type 1 diabetes increases the risk of DKA by an absolute rate of about 4% per year, suggesting the need for intensive diabetes self-management education and monitoring [216, 217]

Pharmacogenomics Genetic polymorphisms in the drug metabolizing enzymes may be an important factor in the differential therapeutic and toxic responses in humans

Vollbracht C, Schneider B, Leendert V, et al

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