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We understand that weight loss is a deeply personal and often emotional process

Systemic effects that have been reported in trials, or that are mechanistically expected from elevated GH and IGF-1, include: Water retention and mild edema , particularly in the hands, ankles, and face Tingling, numbness, or 'pins and needles' (paresthesia) , sometimes linked to fluid pressure on nerves Headache and facial flushing , often shortly after administration Joint aches or stiffness (arthralgia) Transient changes in blood glucose due to GH's counter-regulatory effect on insulin Fatigue, dizziness, or a feeling of light-headedness in some individuals It is important to be candid about the limits of this evidence

Improved comorbidity adjustment for predicting mortality in Medicare populations

However, the weight loss seen in this study of people with type 2 diabetes is broadly comparable with that previously observed with injectable GLP-1