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Using this model, we now demonstrate that Trkb deletion-induced iSPN dysfunction leads to a hyperdopaminergic state in the pre-symptomatic phase, before motor dysfunction onset, reminiscent of the dopaminergic dysfunction observed in the brains of patients with HD 3,4,5

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Alam MS, Hasan MN, Maowa Z, Khatun F, Nazir KHMNH, Alam MZ