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Clinical studies show that participants experienced a mean weight loss of 15% over 68 weeks: In 4 weeks, participants experienced an average of 2% weight loss In 8 weeks, they experienced 4% weight loss The good news is that most of the people in the study lost weight on Wegovy: Over 86% of participants lost at least 5% of their body weight About 70% lost 10% of their body weight or more Note: The FDA has not approved Ozempic and Rybelsus for weight loss