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In Phase II trials, retatrutide achieved up to 24.2% weight loss over 48 weeks, significantly outperforming existing therapies

While the resolution of the cryo-EM map does not allow us to clearly resolve the interactions in this region, our model suggests that the exposure of the carbonyl oxygens in the backbone of Pro 6.47b -Leu-Leu 6.49b enables interactions with polar residues in TM3,5,7 that stabilize the outwards opening of the cytoplasmic half of TM6

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