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In human vastus lateralis biopsies, MGF mRNA rose 4.5-fold 2.5 hours after a single bout of resistance exercise compared with pre-exercise baseline, while systemic IGF-1 did not change significantly, suggesting a paracrine rather than endocrine role [13]

It notes that some providers extrapolate from manufacturer guidance and pregnancy registries, while acknowledging that this remains a genuine gap in clinical evidence rather than an established practice

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