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The FDA says 30 or 27 with comorbidities

Strengths and weaknesses The strengths of this substudy include the methods and design of SUSTAIN 8, a double-blind randomised clinical trial with a global population, relatively long treatment period of 52 weeks, and relevant head-to-head comparison with a glucose-lowering medication with demonstrated efficacy in type 2 diabetes

Some providers allow slightly compressed titration for patients who previously tolerated the medication well, but this should only be done under medical supervision

Keep the medication away from direct contact with ice packs to prevent freezing