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These are all key building blocks for promoting healthy brain function and rebuilding a damaged brain

Insulin acts on -site amyloid precursor protein cleaving enzyme 1 and -secretase to regulate A levels and degrades excess A by modulating insulin-degrading enzyme.147 Activation of insulin signaling pathway PI3k/Akt leads to Ser9 phosphorylation of GSK3 and its impaired kinase activity leads to phosphorylation of tau.148 Hence, IR promotes the pathology of AD by reducing amyloid clearance and increasing tau hyperphosphorylation neurofibrillary tangles,149 both of which are associated with cognitive impairment.150,151 It is widely accepted that changes in the mitochondria are involved in the development of AD

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Biochem Biophys Res Commun (2000) 279:2138