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Antioxidant vitamins and trace elements in critical illness

Glatter wasnt involved in the study

430 Dichloroacetate (DCA), a PDK inhibitor, enhances Krebs cycle flux, preventing myocardial hypertrophy and restoring contractile reserve without altering the expression of key metabolic regulators

When compared to the other analogs in the study, the one that showed the best activity has a 3hydroxy group next to the 4carboxyl, which may have influenced the increase in potency, when compared to the other compounds in the study which were more than 27 times less potent (when compared to the second most potent in the study, the others being even less potent)