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GLP-1 drugs also reduce visceral fat, the metabolically active fat that accumulates around internal organs and Emerging evidence also suggests GLP-1 drugs may influence cellular function in multiple organs, potentially producing widespread effects on aging-related biological pathways

The primary risks include receptor desensitization (reduced pituitary responsiveness to GHRH and ghrelin signaling) after 24-28 weeks of continuous use, potential IGF-1 elevation beyond physiological range if not monitored, and transient side effects like joint discomfort or water retention

PLoS One 11(6):e0156000 Wang D, Curtis A, Papp AC, Koletar SL, Para MF (2012) Polymorphism in glutamate cysteine ligase catalytic subunit (GCLC) is associated with sulfamethoxazole-induced hypersensitivity in HIV/AIDS patients

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