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Subsequent research papers yielded conflicting results (Table 1), but starting from the meta-analysis conducted in 2009 by Medica and coworkers in 623 MDS and 936 control mothers (Medica et al., 2009), all the following meta-analyses confirmed association of this polymorphism with maternal risk for trisomy 21 in the offspring, with overall ORs ranging from 1.2 to 1.6 depending on the genetic model under investigation (Table 2)

Diabetes Care 33(12):25142520

Research shows that melanotan 2 regulates appetite and mediates energy expenditure